Sulforaphene, a radish seed extract, may be a new therapeutic drug for esophageal cancer

Esophageal cancer is one of the top ten common cancers in the world. Previous studies have shown that smoking, excessive consumption of hot tea and red meat, poor oral health and low intake of fresh fruits and vegetables are all associated with esophageal cancer. The overall prognosis of esophageal cancer is not satisfactory due to the fact that most patients are diagnosed with advanced esophageal cancer and the current treatment strategies are limited. Therefore, it is urgent to develop more effective treatment strategies. With the development of cancer related research, many natural active substances, such as astaxanthin and resveratrol, have been proved to have inhibitory effects on a variety of cancers. Among them, isothiocyanates in cruciferous vegetables have attracted more and more attention. SFE isolated from radish seed has strong anticancer activity. This study found that SFE can inhibit the occurrence and development of esophageal cancer. Flow cytometry showed that SFE could induce apoptosis and cell cycle arrest in G2 / M phase. Similarly, cell migration and Transwell chamber experiments showed that SFE could weaken the migration ability of esophageal cancer cells. The results of microarray showed that the effect of SFE on esophageal cancer cells was related to SCD, cdh3, map2k3 and Gadd45b. SCD and cdh3 can promote esophageal cancer metastasis by activating Wnt signaling pathway, and the latter two genes participate in the positive feedback loop of gadd45b-map2k3-p38-p53, thus inhibiting the growth of esophageal cancer. Previous studies have found that Gadd45b is a target gene of p53. In this study, researchers confirmed that Gadd45b can up regulate the phosphorylation level of map2k3 in esophageal cancer cells, thus activating p38 and p53. SFE can increase the expression of map2k3 and Gadd45b, and further stimulate the feedback loop to play a better anti-tumor effect. < / P > < p > original title: < A= target=_ blank>After pregnancy, do not let the wife do these five kinds of housework, the husband should be responsible for it, otherwise it is easy to hurt the fetus!