How does benzbromarone reduce uric acid? How to use it to minimize side effects?

Benzbromarone, a derivative of benzofuran, is an excretory drug of uric acid. By inhibiting the reabsorption of uric acid by renal tubules, the excretion of uric acid is increased and the concentration of serum uric acid is reduced. It can also promote the re dissolution of uric acid crystals, prevent the deposition of uric acid crystals and the formation of uric acid crystals in tissues, and reduce joint injury. It is mainly used in primary and secondary hyperuricemia, gout caused by various reasons and gouty arthritis

benzbromarone is easy to be absorbed by oral administration. It has a strong effect of reducing blood uric acid. It can not only relieve pain, reduce redness and swelling, but also dissipate gout nodules. More than 90% of hyperuricemia is mainly caused by the decrease of uric acid excretion in kidney. Benzbromarone reduces the concentration of serum uric acid by promoting the excretion of uric acid. It has a good effect on reducing uric acid and less side effects, so it is recommended as a representative drug in China.

hyperuricemia is closely related to gout, and it is an independent risk factor for hyperlipidemia, diabetes, chronic kidney disease, metabolic syndrome, cardio cerebrovascular disease and stroke. Gout is a disease directly related to hyperuricemia. It is necessary to manage the level of uric acid. It should be strictly controlled below 360 μ mol / L, preferably 300 μ mol / L, and maintained for a long time. For asymptomatic hyperuricemia, active stratified treatment should also be given.

3. The main manifestations were anorexia, nausea, vomiting, general fatigue, abdominal pain, diarrhea, fever, yellow urine color, yellow eye conjunctiva. If you have the above symptoms during the medication, please stop taking the medicine immediately and see a doctor.

5. Skin allergy symptoms such as wheeze, rash, eczema, photosensitive reaction, flushing and itching can be seen on the skin. There are also reports of severe pustules and ecchymosis on the skin, and the symptoms can gradually disappear after drug withdrawal. 08/16/2020