In the twinkling of an eye, September has come, the symptoms of lumbar muscle strain, ligament injury, arthritis, trauma and other orthopedic diseases are aggravating, especially for patients with osteoarthritis, entering the autumn, the condition begins to deteriorate, leading to increased pain. For the elderly patients, in order to deal with the unbearable pain, they started early protective measures. Keep the sick part warm with protective equipment such as kneepads, or scald feet with hot water. However, the treatment of osteoarthritis is not a joke. If it is not treated in time, it is only blindly taking protective measures, and the final consequences are even more terrible.
osteoarthritis is a very common disease, patients often accompanied by local joint stiffness, dull pain, joint swelling, bone friction and other symptoms. It seriously affects the quality of life, and once the disease occurs, it can not be cured for a long time. It brings huge economic burden to patients and families. According to the research results of China Health and pension tracking survey database, there are about 113.4 million knee osteoarthritis patients in China, and the disability rate is as high as 53%. It is expected to become the fourth major disability disease by 2020. Among them, the middle-aged and the elderly are the high-risk population, and the prevalence rate of people over 65 years old is more than 50%, and the female patients are higher than the male patients. Although the incidence rate of
is high, the pathogenesis of osteoarthritis is not clear. The pathogenesis is related to heredity, age, obesity and trauma. It is generally believed that it is the result of biomechanical factors that destroy the normal coupling of chondrocytes, extracellular matrix and subchondral bone.
patients with osteoarthritis can be protected by reasonable joint muscle exercise, usually reducing joint weight bearing and correcting sitting posture. In autumn, as the weather gets cooler, joint parts should pay more attention to keep warm, avoid humid, cold and windy environment, and protect joints from freezing.
in addition to daily protection, patients also need timely treatment. At present, the treatment methods of osteoarthritis include surgical treatment and non-surgical treatment. Surgical treatment has problems such as high cost, pain, prosthesis loosening resulting in secondary operation, which is not easy to be accepted by patients. Therefore, clinical treatment is mainly non-surgical treatment, and patients have high compliance. In terms of drug treatment, the commonly used drugs include six categories: nonsteroidal anti-inflammatory drugs, analgesics, intra-articular injection drugs, slow acting drugs to relieve symptoms, anti anxiety drugs and Chinese patent medicines.
in recent years, new research results also provide new ideas for the alleviation and treatment of osteoarthritis. Authoritative research shows that the excessive degradation and loss of glucosamine in cartilage matrix may be one of the important reasons for cartilage degeneration. This also makes taking glucosamine become an important means to relieve the symptoms of osteoarthritis. At present, the ammonia salts used in the treatment of osteoarthritis are mainly divided into ammonia hydrochloride and ammonia sulfate. The former has simple molecular structure and is often used as food additives and health products, while the latter is more complex and commonly used in drugs. It is also because of this, patients often take ammonia hydrochloride health products to alleviate the treatment with “low burden” psychological cognition, but found that after a long time, did not achieve the expected treatment effect. In fact, some clinical data show that the clinical efficacy of glucosamine hydrochloride is equivalent to that of placebo. In contrast, ammonium sulfate is the precursor of Glucosaminoglycan in cartilage, which can stimulate chondrocytes to produce Glucosaminoglycan with normal polymer structure, promote the synthesis and repair of cartilage matrix; in addition, ammonium sulfate can also inhibit the production of inflammatory factors, so as to relieve joint pain, improve joint function and delay the progress of the disease.
However, at present, the commonly used ammonia sulfate is a mixture of sulfate and sodium chloride. One of its major weaknesses is that it has very strong hygroscopicity, the concentration cannot be guaranteed, and the therapeutic effect is naturally limited. Therefore, the medical community began to study the higher concentration of ammonia sulfate. In 2001, reginster et al. Reported a randomized, double-blind, placebo-controlled clinical study of glucosamine sulfate in the treatment of knee OA in Lancet. The follow-up time was as long as 3 years. A total of 212 patients were selected. The results showed that crystalline ammonium sulfate had obvious curative effect on osteoarthritis and slowed down the progress of joint destruction. It is found that the concentration of the drug in synovial fluid of this kind of ammonia is about three times of that of ammonia hydrochloride.
although the therapeutic effect of crystalline ammonia sulfate has been certified, there are not many such drugs on the market due to the high cost of research and development. Among them, glucosamine sulfate capsules produced by Zhejiang Haizheng Pharmaceutical Co., Ltd. is the representative of crystalline ammonia sulfate drugs. It is reported that esophage is the first glucosamine to pass the consistency evaluation and carry out the human be experiment. Its structural stability has been tested by XRPD, DSC and other tests, which successfully overcomes the disadvantage of strong hygroscopicity of ordinary glucosamine sulfate. Meanwhile, its bioavailability and half-life are higher than that of glucosamine hydrochloride. It is the only one that can effectively inhibit articular cartilage Degraded glucosamine.
in addition, esophage is the first imitation of glucosamine sulfate in China. It has a new drug certificate, and is the only one of all glucosamine manufacturers in China that has done phase III clinical treatment of large cases in accordance with the national requirements. It not only ensures the curative effect, but also reduces the burden of drug purchase, and can help patients with bone and joint get rid of the pain better.
of course, prevention is the best treatment. Today, osteoarthritis is not exclusive to middle-aged and elderly people. Bad living habits, improper exercise, work and study pressure may lead to illness. Therefore, we should pay attention to joint protection, avoid excessive joint strain, control weight, and reduce the risk of osteoarthritis as much as possible. In addition, we also need to improve the understanding of it, once the suspected symptoms appear, early treatment, standardized treatment, to maximize the delay of disease progression, protect joint function. Pregnant dream “Golden Dragon” is about to “give birth to a boy”? You think too much, the function of fetal dream is not here