Slow down your heart, and you’ll live longer? Correct understanding of “lol” antihypertensive drugs

A friend with high blood pressure told huazi that his heart rate was too fast. The doctor told him to take antihypertensive drugs like lol to control his blood pressure, and told him that this drug can slow down his heart rate. He asked Hua Zi, does the doctor mean that a person’s heart rate has a “fixed number” and that the one who finishes the jump first will go first, so he uses drugs to slow down his heart rate to treat his hypertension? < / P > < p > huazi replied that he thought a little too much. It was because he was always cranky, leading to anxiety and tension, that the sympathetic nerve tension increased, the heart rate increased, the cardiac output increased, and eventually the blood pressure increased. That’s why the doctor chose NOLS to lower his heart rate and help him control his blood pressure. < / P > < p > the normal range of resting heart rate is between 60 and 100. People who like sports will have stronger heart and more stroke volume, so their heart rate will be slower. And people who exercise regularly have better health and longer life expectancy. But it should be understood that the reason for the longevity of people who love sports is to keep the good habit of sports, not the slow heart rate. < / P > < p > everyone’s life span is related to many factors, such as heredity, age, gender, physical fitness, disease and so on. In healthy people, if the heart rate is slower in the normal range, the oxygen consumption of the myocardium will be lower, which is more beneficial to health, but not necessarily longer. < / P > < p > the formal name of NOLS in antihypertensive drugs is beta blocker. Because the name of this kind of drugs carries “lol”, it is called NOLS for short. The effect of these drugs is to inhibit the activity of β 1 receptor in the heart. The β 1 receptor is like a “switch” on the heart. When the β 1 receptor is activated, it is like turning on the “switch”, which makes the heart excited, increases the heart rate and strengthens the contractility. However, LORs can turn off the “switch”, weaken the excitability of the heart, slow down the heart rate, weaken the contractility of the myocardium, reduce blood pressure and oxygen consumption of the myocardium. Moreover, lol can also reduce renin secretion and inhibit renin angiotensin aldosterone system, which is a commonly used antihypertensive drug. It can be used alone or in combination with other drugs. It is especially suitable for young hypertensive patients with excessive renin secretion and excessive sympathetic activation. < / P > < p > NOLS can slow down the heart rate, so it is more suitable for hypertensive patients with tachyarrhythmia. It can reduce myocardial oxygen consumption and angina attack in patients with coronary heart disease. It can also protect the heart after chronic heart failure and myocardial infarction. < / P > < p > when using LORs, we should pay attention to the great individual differences of these drugs, and the effective dose of different patients may vary several times. Therefore, under the guidance of doctors, we should start from low dose, gradually increase the dose, and “explore” the most suitable dose for ourselves. < / P > < p > food will increase the absorption of NOLS, which will cause a significant fluctuation of blood pressure, so we should take medicine on an empty stomach to maintain the stability of blood pressure. There is β 2 receptor in the bronchus, when it is inhibited, it will make the bronchus constrict and induce asthma. Therefore, people with asthma are not recommended to use NOLS. Or, under the guidance of doctors, we should be cautious in the use of LORs which are highly selective for β 1 receptor. < / P > < p > in the long-term administration of LORs, the long-term inhibition will increase the sensitivity of cardiac β 1 receptor. If the drug is stopped suddenly, the β 1 receptor will be over activated, resulting in “rebound phenomenon”, which is manifested as the aggravation of hypertension, angina pectoris and arrhythmia. Therefore, the dosage should be reduced gradually during withdrawal, the whole process should be no less than 2 weeks, the dosage should be halved every 3 days, and the last dosage should be no less than 4 days before withdrawal. < / P > < p > people with bradycardia and severe atrioventricular block are not suitable for NOLS. Alcohol can reduce the effect of NOLS, so it is necessary to abstain from alcohol during medication. If you need to take the same medicine, consult your doctor or pharmacist in advance. < / P > < p > to sum up, the speed of heart rate is not necessarily related to the length of life. NOLS can slow down the heart rate, reduce blood pressure and protect the heart. When taking them, you need to be guided by a doctor. If problems are found in the course of taking medicine, consult a doctor or pharmacist in time. I am a pharmacist huazi, welcome to pay attention to me, let me be your pharmacist. PARRENT&CHILDREN