To understand this biological mechanism, perhaps human beings will not be afraid to stay up late any longer

But when a sleep deprived animal dies, the body outside its nervous system experiences a series of puzzling failures. For example, people with long-term lack of sleep may have heart disease, high blood pressure, obesity, diabetes, etc. Recently, roglia, a neuroscientist at Harvard Medical School, and her colleagues published a paper in the journal. They found that sleepless can lead to the accumulation of reactive oxygen species in the intestine of Drosophila melanogaster, leading to the death of Drosophila melanogaster. After neutralizing these reactive oxygen species, fruit flies can survive even if they don’t sleep. < p > < p > People’s research mainly focuses on the brain, and more previous studies believe that sleep deprivation affects more the function of the nervous system. The study found that sleep deprivation can lead to death through the accumulation of reactive oxygen species in the gut, and that death can be avoided by neutralizing reactive oxygen species. < / P > < p > a large number of studies have shown that staying up for a long time can lead to premature death of animals. In order to understand what this process is like, most researchers focus on the brain, but there is no definite conclusion so far. < / P > < p > in 2016, Harvard neurobiology researcher Alexandra wacaro and others obtained genetically modified Drosophila from other laboratories to provide temperature sensitive channels in some neurons. When the temperature is above 28 ℃, these channels remain open, their neurons remain active and the flies are awake all the time. At this time, because of sleep deprivation, they begin to die in about 10 days, and all of them die within 20 days. When the passage is closed, the flies can rest normally, and their life span is usually 110 days. < p > < p > Alexandra wacaro has found that flies can recover from severe sleep deprivation and have a normal life span < / P > < p > if they shut down the channel and let them sleep on the 10th day, they will recover and live about 110 days. But if they open the channel again on the fifth or tenth day of their recovery process, so that the flies can’t rest, they will die, and it’s clear that whatever damage they caused in their initial insomnia has not been repaired. They need 15 days of normal sleep before they are deprived of sleep again without immediate death. When vacaro dissected Drosophila melanogaster with different degrees of sleep deprivation, it was found that none of their tissues was damaged, but their viscera were full of ROS. < / P > < p > these ROS are highly reactive oxygen molecules, which can destroy DNA and other components of cells, leading to cell death. The accumulation of ROS reached its peak on the 10th day of sleep deprivation, and decreased when deprivation stopped. < / P > < p > it was also confirmed in mouse experiments that ROS would accumulate in the intestine during sleep deprivation. More experiments have shown that only animals that lose sleep continuously accumulate ROS, and the gut is indeed the main source of this deadly ROS. < / P > < p > to find out whether ROS in the gut plays a causal role in death after sleep deprivation, researchers began to test whether inhibition of ROS accumulation can prolong the survival time of animals. < / P > < p > they tested dozens of compounds with antioxidant properties that are known to neutralize ROS, and found that several compounds, as food supplements, can give sleep deprived flies a normal or near normal life span, such as melatonin and lipoic acid. The experiment of excessive production of antioxidant enzymes in Drosophila intestines further confirmed that the removal of ROS played an important role in the prevention of death, but the control Drosophila with excessive production of antioxidant enzymes in the nervous system was not. George gilstrow, a sleep researcher at Imperial College London, points out that these experiments clearly show that reactive oxygen species can kill flies, but this does not necessarily mean that reactive oxygen species are the only culprit. < / P > < p > there is another study that shows that the intestinal microbiota shifts after sleep loss, which opens the door to the study of the relationship between sleep loss and death. < / P > < p > nevertheless, the most pressing question is: no one knows where ROS comes from and why they accumulate in the gut, and what are the processes that produce these metabolism? Can sleep deprivation lead to excessive ROS production? Or will it interfere with some of the processes that are usually cleared < / P > < p > all these questions will be unveiled in the future. But for humans, it reminds us once again that sleep is very important. It not only affects the brain, but also causes problems in the stomach and intestines, which can lead to death. < / P > < p > these sleep deprived flies remind us that sleep is a whole body experience, not just a brain and brain function. In their death, there may be hidden causes of death caused by insomnia, as well as the role of sleep in connecting different systems of the body. 08/16/2020