After infecting new coronavirus, why can some people get severe disease, and some people won’t? This has always been a mystery. Now, novel coronavirus pneumonia is a new study of the disease. Now, scientists in the latest issue of the journal write that their latest research suggests that immune deviation and failure may lead to differences between severe and mild patients with new crown pneumonia.
the researchers explained that this immune bias may be due to the different responses of our innate immune system to the new coronavirus. From Drosophila to humans, all organisms have innate immune systems that can quickly sense viruses and other pathogens. Once the virus is sensed, the innate immune system will immediately attack them indiscriminately, and mobilize the “sharpshooter” cells that can carry out more accurate attack but slower speed. This kind of cell belongs to another branch of human pathogen defense system – adaptive immune system.
researchers analyzed the novel coronavirus pneumonia and 69 healthy people’s immune response in 76 cases. They found that in novel coronavirus pneumonia patients, the molecular concentration of their blood inflammatory reaction increased, and they identified 3 molecules that were also related to other pulmonary inflammation. The novel coronavirus pneumonia animal model is considered novel coronavirus pneumonia.
researchers believe that these 3 molecules and their receptors may be targets for treating new crown pneumonia. They are testing the therapeutic potential of blocking these molecules in the new crown pneumonia animal model.
novel coronavirus pneumonia has also shown that the increased concentration of bacterial debris in the blood of the patients with severe acute respiratory syndrome is more severe, and the more severe the disease is, the more inflammatory substances are circulating in the blood. Moreover, in novel coronavirus pneumonia patients, bacteria products usually present in the intestines, lungs and larynx may enter the blood, thereby enhancing the inflammatory reaction and transmitting them through the circulatory system to all parts of the body. Novel coronavirus pneumonia is also found to be a key factor in the innate immune system of new crown pneumonia patients, but the
is not responsive to the presence of viruses or bacteria, the study also found.
Dr. Barry pledella, senior author of the paper and from Stanford University School of medicine, said: “these findings reveal how the immune system can make mistakes and cause serious diseases during the infection of new coronavirus, and point out potential therapeutic targets.” Your name will always exist on the Internet