Zhou Jielun, Zhang Jia translated “immortal cancer”, can infect? Can’t have children?

The two stars, Jay Chou and Zhang Jiayi, believe that they will not be unfamiliar. However, fate has played a joke on them. Although they are both very popular, they also have a disease called “immortal cancer” – ankylosing spondylitis. < / P > < p > who ever thought that Jay Chou had to endure pain when he was dancing on the stage; who had ever thought that how many nights Jay Chou could only sit and sleep; and who had ever thought that Zhang Jiayi’s unrecognized Internet red pace was actually caused by ankylosing spondylitis. For ankylosing spondylitis, people are often worried that inflammation will be contagious, will be inherited, can not have children, I will come to science today. Ankylosing spondylitis is a chronic inflammatory disease, mainly involving sacroiliac joint. Generally, this kind of inflammation starts from sacroiliac joint and gradually develops to lumbar vertebra, thoracic vertebra and cervical vertebra, with pain in corresponding parts, and spinal deformity and ankylosis may occur in severe cases. The prevalence of ankylosing spondylitis in China is about 0.3%, and the ratio of male to female is about 2-3:1. The incidence of ankylosing spondylitis in women is relatively slow and the symptoms are mild. The age of onset is usually between 13 and 31 years old, with a peak of 20-30 years old. The etiology of ankylosing spondylitis (as) has not been studied clearly, and it is found from epidemiological investigation that it is closely related to genetic and environmental factors. It has been confirmed that the disease is closely related to human leukocyte antigen, and has an obvious tendency of family aggregation. In the late stage, the typical manifestation is “slubby change”. There is a close relationship between ankylosing spondylitis and HLA-B27. HLA-B27 gene is a part of genetic material DNA existing in the nucleus of human cells. It belongs to type I MHC gene, which is basically expressed on all nucleated cells, especially on the surface of lymphocytes. The positive rate of HLA-B27 in ankylosing spondylitis is about 90% in China. So many people are worried about the presence of this gene. Jay Chou’s uncle is also ankylosing spondylitis. Therefore, including Jay Chou, he also expressed his concern about the heredity of the disease in public. He was very worried that the child born must be ankylosing spondylitis. As shown in the above figure, in fact, not all HLA-B27 positive patients are ankylosing spondylitis, on the contrary, most HLA-B27 positive patients do not develop ankylosing spondylitis. Therefore, ankylosing spondylitis will be inherited is a rumor, of course, there is no saying that children can not be born. We can imagine that Jay Chou’s father did not have ankylosing spondylitis. In addition, not all patients with ankylosing spondylitis are HLA-B27 positive. In China, 5% – 10% of patients with ankylosing spondylitis are negative for HLA-B27. Therefore, although ankylosing spondylitis is closely related to HLA-B27, whether it is directly related to HLA-B27 and its etiology need further study, which may be the result of multiple factors. < p > < p > occult onset, pain in the back or sacroiliac region and morning stiffness gradually appeared; nocturnal pain may wake up in the middle of the night. It can be explained as follows: pain of bilateral lumbar vertebra or spasmodic pain after multiple months of sitting; it can also be explained by the pain of bilateral lumbar vertebra or pain of pain after sitting and sneezing In the late stage, severe spinal deformity may occur. There may be other joint and extraarticular inflammatory lesions and mild systemic manifestations. The above symptoms are the performance of aseptic inflammation, which is to be distinguished from bacterial infectious inflammation. There are no bacteria and viruses in the inflammation of ankylosing spondylitis, which is the result of inflammatory factors. Therefore, ankylosing spondylitis has the general characteristics of aseptic inflammation: < / P > < p > will not fester; bacteria, viruses and other pathogens can not be detected; if there is no pathogen, there will be no infection; the use of non steroidal anti-inflammatory drugs, TNF – α antagonists, hormones and other anti-bacterial inflammatory drugs are effective. Summary: < A= https://luanban.com/21-days-after-delivery-the-pregnant-woman-had-a-new-baby-but-the-doctor-did-not-find-it-was-twins/ target=_ blank>21 days after delivery, the pregnant woman had a new baby, but the doctor did not find it was “twins”